AIs have been shown to cause arthralgia in up to 46% of patients [10], which can be difficult to treat and can negatively impact quality of life and become potentially persistent with therapy, which makes it obliged to look for effective treatments [5, 11, 12]. devotees of traditional Chinese medicine: tiger bone wine. Health-Related Quality of Life (HRQoL) was measured by the Functional Assessment of Cancer Therapy-Breast (FACT-B). Lv, and Z.-L. Sun, “Clinical study of acupuncture intervention in muscle, bone and joint pain caused by aromatase inhibitors in the treatment of breast cancer,”, J. J. Mao, D. W. Bruner, C. Stricker et al., “Feasibility trial of electroacupuncture for aromatase inhibitor—related arthralgia in breast cancer survivors,”, H. Greenlee, K. D. Crew, T. Shao et al., “Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer,”, M. Kubo, H. Onishi, S. Kuroki et al., “Short-term and low-dose prednisolone administration reduces aromatase inhibitor-induced arthralgia in patients with breast cancer,”, M. L. Galantino, K. Desai, L. Greene, A. Demichele, C. T. Stricker, and J. J. Mao, “Impact of yoga on functional outcomes in breast cancer survivors with aromatase inhibitor-associated arthralgias,”, N. Peng, Y. Zhang, C. Ma et al., “Effects of the traditional Chinese medicine Yi Shen Jian Gu granules on aromatase inhibitor-associated musculoskeletal symptoms: A Study Protocol For A Multicenter, Randomized, Controlled Clinical Trial,”, H. X. Zhongshen Liu and G. Li, “Effects of collagen factor on aging mice bone strength and composition,”, R. L. Yuming Fan, “Effects of bionic tiger bone on osteoporosis caused by tretinoin of rats,”, R. H. Dworkin, D. C. Turk, K. W. Wyrwich et al., “Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations,”, J. Kitawaki, “Review Endometriosis: the pathophysiology as an estrogen-dependent disease,”. Dr. Wenping Lu received financial support from National Natural Science Foundation of China (NSFC), H2902 and H2704. And TB group showed a significant improvement at physical well-being on week 12 (). Send Facebook Twitter reddit EMail Facebook Messenger Web Whatsapp Web Telegram linkedin. Sign up here as a reviewer to help fast-track new submissions. In traditional Chinese medicine (TCM), tiger bone is used to treat chronic pains by its functions of strengthening the muscles and bones, expelling wind and cold, and relieving pain and convulsion [6]. Dr. Wenping Lu, Yifan Li, Zhenhua Zhang, Feifei Cui, Jialing Liu, Yitong Wang, Juling Jiang, and Wenxin Ma approved of the final manuscript. Osteostrong is a franchise brand that offers osteogenic loading. Copyright © 2017 Yifan Li et al. Between May 2015 and May 2016, 72 participants were enrolled and completed baseline questionnaires; 70 of them were evaluable. Most patients in China moved to TCM (traditional Chinese medicine) for help. Consequences are that AIMSS not only impairs the quality of patients’ life, but also hinders their compliance, which will definitely disrupt further treatments. The dual-acting type of osteoporosis medication helps build bone while reducing bone density loss. Our study indicates that TB can play an important role in assisting traditional Chinese herbal medicine in the long-term treatment for AIMSS, in order to alleviate adverse reaction and improve the quality of life much better. © 2020 Deutsche Welle | After the announcement, China's Sina Weibo erupted with criticism. FACT-B was used as the secondary outcome. 72 patients were enrolled, of which 70 were evaluable. 5, Beixiange, Xi Cheng District, Beijing 100053, China. That is mainly because postmenopausal women with AIMSS usually exhibit a specific pathological change associated with deficiency of kidney essence, such as pain, stiffness, and dysfunction [25]. Of the 35 patients in TB group, 8 of them (22.9%) developed new or worsening joint symptoms, compared with 21 of 35 (60%) in placebo (). The endangered animals are bred for luxury items, like tiger bone wine and tigerskin rugs. Most patients in China moved to TCM (traditional Chinese medicine) for help. Both medicines were asked to be taken with an interval of more than half an hour from AI and lasted 12 weeks. The device is … Generally speaking, osteoporosis medications work by either stopping bone loss or by stopping bone loss and increasing bone density (“antiresorptives”). This trial is registered with ChiCTR-IPR-15007081. The objective of this study was to evaluate whether the TB prevented AIMSS in postmenopausal women with ER/PR+ breast cancer. Pungent, warm; liver and kidney meridians entered. According to Zhang, rhino horn powder has been shown to relieve symptoms of fever. No real tiger bone wine in China, China has less than 30 wide tigers, like 6-7 k tigers in the zoo. Based on that, treatments should focus on tonifying the kidney, fortifying the bone, and dispelling the pathogenic factors. Joint pain and headaches are common side effects. Patients completed the M-BPI, VAS, and FACT-B at baseline, 6 weeks, and 12 weeks. We described demographic, clinical, and outcome variables by using means and standard deviations for continuous variables and percentages for categoric variables by treatment group. Participants in TB group were given tiger bone powder made into capsules, which have been approved by China Food and Drug Administration (CFDA: Z20030080) to treat arthralgia, and the recommended dose is 1.2 g, 3 times daily. Modern pharmacological research has shown that bionic TB powder has more than 20 kinds of amino-acid and microelements essential to human. There was no reason given for removing the ban and the announcement drew condemnation from wildlife activists along with doctors of traditional Chinese medicine and Chinese consumers. I don't know why Kim has real tiger bone wine either, I've never been to North Korea. Considering that breast cancer is a hormone-related disease, we also assayed estradiol () and follicle-stimulating hormone (FSH) from patients’ serum samples at the baseline, week 6, and week 12 time point, so as to see if the intervention would influence patients’ hormone levels. We are committed to sharing findings related to COVID-19 as quickly as possible. In the UK there are shops that sell traditional Chinese medicine and some of these products contain tiger bone. 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